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6 Step Mac and Cheese Meatloaf Casserole

The Origins of Meatloaf Meets Mac and Cheese

Meatloaf is a classic American dish that became popular in the 20th century as a budget-friendly way to stretch ground beef with bread crumbs and eggs. Macaroni and cheese, on the other hand, has deep roots in Southern comfort cooking and has been a staple in American homes since the 1800s. Combining the two into one casserole takes the best of both worlds: a savory, hearty meatloaf base topped with creamy mac and cheese. This mash-up has grown in popularity for its all-in-one meal quality, bringing together two beloved comfort foods into a single, satisfying dish.

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Why These Ingredients Work Together

The ground beef, bread crumbs, and eggs form a classic meatloaf base that holds its shape while remaining tender. Macaroni adds a soft, starchy layer that balances the richness of the beef. Cheddar cheese melts over the top, creating gooey texture and bold flavor. The milk and ketchup sauce poured over the casserole not only keeps the dish moist during baking but also adds tangy sweetness that contrasts with the savory layers. Together, these ingredients create a dish that’s hearty, cheesy, and flavorful in every bite—perfect for family dinners or potlucks.

Why You’ll Love Making This Recipe

This recipe is a family favorite because it’s simple, budget-friendly, and incredibly filling. It only requires pantry staples, comes together in about an hour, and bakes in one dish—making it both easy to prepare and easy to clean up. Kids especially love the combination of cheesy pasta and meatloaf, while adults appreciate how satisfying and comforting it is. The recipe is also versatile: you can swap ground beef for turkey or chicken, add vegetables like peas or spinach, or experiment with different cheeses. With minimal effort, you’ll have a warm, hearty casserole that everyone at the table will enjoy.

Ingredients

  • 1 lb ground beef
  • 1 cup bread crumbs
  • 2 eggs
  • 1 cup shredded cheddar cheese
  • 1 cup macaroni noodles, cooked
  • 1 cup milk
  • 1 cup ketchup
  • Salt and pepper, to taste

Step-by-Step Instructions

Step 1: Preheat the Oven

Preheat oven to 375°F (190°C).

Step 2: Make the Meatloaf Base

In a bowl, mix ground beef, bread crumbs, eggs, salt, and pepper. Press evenly into the bottom of a greased baking dish.

Step 3: Add Macaroni and Cheese

Top the meatloaf mixture with cooked macaroni noodles and shredded cheddar cheese.

Step 4: Prepare the Sauce

In a separate bowl, whisk together milk and ketchup until smooth. Pour evenly over the casserole.

Step 5: Bake

Bake uncovered for 45 minutes or until the meatloaf is cooked through and bubbling.

Step 6: Rest and Serve

Allow casserole to cool for a few minutes before slicing and serving.

Timing

  • Prep time: 15 minutes
  • Cook time: 45 minutes
  • Total time: 1 hour

Nutrition (per serving, approx. 6 servings)

  • Calories: 420
  • Protein: 25g
  • Carbohydrates: 30g
  • Fat: 20g
  • Fiber: 2g
  • Sodium: 780mg

Mac and Cheese Meatloaf Casserole

Q1: Can I prepare this casserole ahead of time?

Yes! Assemble the casserole up to the baking step, cover tightly, and refrigerate for up to 24 hours. Bake when ready to serve, adding 10 extra minutes if chilled.

Q2: Can I freeze this dish?

Absolutely. Bake the casserole, let it cool, then wrap tightly in foil. Freeze for up to 3 months. Reheat in the oven at 350°F until heated through.

Q3: What other cheeses can I use?

Cheddar is classic, but mozzarella, Monterey Jack, or even a sharp provolone can add a different flavor twist.

Q4: Can I make it healthier?

Yes. Substitute ground turkey or chicken for beef, use whole wheat macaroni, and reduce cheese or choose a lighter variety.

Q5: What should I serve with this casserole?

It’s hearty on its own, but a fresh green salad, roasted vegetables, or garlic bread make great sides.

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