The Origins of Cajun Cuisine and Its Bold Flavors

Cajun cuisine comes from Louisiana, USA, and is known for its bold, spicy, and rustic flavors. It blends French cooking traditions with local Southern ingredients, creating a cuisine that is hearty and full of depth. Cajun seasoning is a mix of paprika, garlic powder, onion powder, cayenne pepper, oregano, and thyme, giving every dish a smoky, spicy, and savory punch. In this recipe, Cajun spices are used to season tender chicken breast and create the base for a creamy sauce. When combined with butter, garlic, and Parmesan, the flavors balance perfectly—spicy yet comforting. This pasta dish reflects the Cajun spirit: simple, satisfying, and layered with flavor.

Why Garlic Butter and Parmesan Make the Perfect Pair

Garlic butter is one of the most beloved flavor bases in cooking, used in cuisines worldwide. Garlic brings warmth and aroma, while butter provides richness and a silky texture. In this recipe, sautéing garlic in butter enhances the Cajun seasoning and creates a sauce base that feels luxurious. Parmesan cheese takes it a step further—it melts into the cream and broth, thickening the sauce naturally and adding a salty, nutty flavor. Parmesan is high in protein and calcium, making the dish not only delicious but also nourishing. Together, garlic butter and Parmesan elevate the pasta, creating a creamy, restaurant-quality sauce that clings to every bite of penne.

The Comfort of Creamy Cajun Pasta

Cajun Garlic Butter Chicken Penne is more than just a pasta dish—it’s comfort food at its best. The combination of tender chicken, creamy Parmesan sauce, and perfectly cooked penne creates a meal that is both filling and indulgent. It’s versatile enough for a weeknight dinner yet impressive enough for guests. Adding Cajun spices ensures every bite has a kick, while fresh parsley brings balance and brightness. This recipe is also beginner-friendly: one pot for the pasta, one skillet for the sauce, and you have a complete meal in under an hour. Serve it with garlic bread or a side salad for a wholesome and satisfying dinner.

Ingredients

2 boneless, skinless chicken breasts, cut into bite-sized pieces
2 tablespoons unsalted butter
4 cloves garlic, minced
1 tablespoon Cajun seasoning
1/2 teaspoon smoked paprika
Salt and pepper, to taste
1 cup heavy cream
1/2 cup chicken broth
1/2 cup grated Parmesan cheese
8 oz penne pasta
1 tablespoon olive oil
Fresh parsley, chopped (for garnish)

Instructions

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil. Add penne and cook until al dente according to package instructions. Drain and set aside.

Step 2: Season and Cook the Chicken

Season chicken pieces with salt, pepper, Cajun seasoning, and smoked paprika. Heat olive oil in a large skillet over medium-high heat. Cook chicken for 6–7 minutes until golden and fully cooked. Transfer to a plate.

Step 3: Build the Sauce Base

In the same skillet, melt butter. Add minced garlic and sauté for 1–2 minutes until fragrant. Stir in remaining Cajun seasoning to infuse the butter with flavor.

Step 4: Make It Creamy

Pour in chicken broth and heavy cream. Simmer for 4–5 minutes until the sauce thickens. Stir in Parmesan cheese until smooth and creamy. Adjust salt and pepper to taste.

Step 5: Combine and Serve

Add cooked chicken and pasta back to the skillet. Toss until the penne is coated with sauce. Garnish with fresh parsley and extra Parmesan before serving warm.

Recipe Timing & Nutrition

Prep Time: 15 minutes
Cook Time: 25 minutes
Total Time: 40 minutes
Servings: 4

Nutrition (per serving):

Cajun Garlic Butter Chicken Penne

1. Can I use another type of pasta instead of penne?

Yes! While penne works best because it holds the creamy sauce in its ridges, you can use fettuccine, rigatoni, or even spaghetti. Short pastas with ridges are preferred because they trap more sauce, making each bite flavorful.

2. How can I make this recipe healthier?

To lighten it up, replace heavy cream with half-and-half or evaporated milk. You can also use whole wheat pasta for added fiber. Adding vegetables like spinach, bell peppers, or mushrooms boosts nutrition while keeping it hearty.

3. Can I make this dish ahead of time?

Yes, but it’s best enjoyed fresh. If reheating, add a splash of milk or broth to loosen the sauce, as creamy pastas tend to thicken when refrigerated. Store in an airtight container in the fridge for up to 3 days.

4. What protein substitutes can I use instead of chicken?

Shrimp, sausage, or even tofu work well with Cajun seasoning. Shrimp cooks quickly and pairs wonderfully with garlic butter. Sausage adds extra smoky depth, while tofu is a great vegetarian alternative.

5. How spicy is this recipe?

It has a medium spice level thanks to Cajun seasoning and smoked paprika. If you prefer it milder, reduce the Cajun seasoning by half. To make it spicier, add cayenne pepper or hot sauce to taste.

5 Steps to Make Cajun Garlic Butter Chicken Penne